Abstract
The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.
Highlights
Poly(ethylene) glycols (PEGs) are eco-friendly solvents [1,2], finding applications in the biomedical field and for pharmaceutical formulations [3] and catalysis [4]
The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents
We firstly reported the positive influence of PEG solvents as grinding agents for the mechanochemical preparation of an active pharmaceutical ingredient (API), the anticonvulsant drug ethotoin 7 [9]
Summary
Poly(ethylene) glycols (PEGs) are eco-friendly solvents [1,2], finding applications in the biomedical field and for pharmaceutical formulations [3] and catalysis [4]. Cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.
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