Abstract
New nanogels (NGs) with tailored properties were obtained using a mini-emulsion technique, from poly(ethylene glycol) diacrylate (PEGDA) self-crosslinking macromers of various molecular weight. By modifying synthesis parameters (hydrophilic-lipophilic balance, emulsifier and the ratio of organic-aqueous medium), optimum recipes of NGs were selected. Therefore, the molecular weight distribution and the functionalization degree of the PEGDA2000 macromer were assessed by Gel Permeation Chromatography (GPC) and Nuclear Magnetic Resonance (NMR), respectively. Furthermore, the PEGDA-NGs were investigated by Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) for size distributions and morphology. DLS and TEM results confirm that these new PEGDA-NGs hold potential for biomedical applications.
Highlights
New nanogels (NGs) with tailored properties were obtained using a mini-emulsion technique, from poly(ethylene glycol) diacrylate (PEGDA) self-crosslinking macromers of various molecular weight
Chromatography were investigated by Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) for size distributions and morphology
DLS and TEM results confirm that these new PEGDA-NGs hold potential for biomedical applications
Summary
New nanogels (NGs) with tailored properties were obtained using a mini-emulsion technique, from poly(ethylene glycol) diacrylate (PEGDA) self-crosslinking macromers of various molecular weight. The most frequent methods used for micro- and NGs synthesis are usually heterogeneous polymerization processes like (i) polymerization in inverse mini- or microemulsion (oil -water), which involves a stable mixture composed of water-soluble polymer-surfactant assemblies in a continuous organic medium [6], and (ii) precipitation polymerization that begins as a continuous phase, in which the monomer and the initiator are completely soluble, followed by polymer growth and precipitation as the molecular weights increase [7]. The latter method presents several drawbacks i.e. low yields of preparation, irregular particle shapes and high polydispersity indexes (PDI) [8]. Shimoda and coworkers [10] obtained polyethylene glycol (PEG)/ polysaccharides hybrid NGs, to be used as nanocarriers and controlled release systems for proteins
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