Abstract
A biocompatible and water-soluble poly(amino acid) derivative, with a hydrophilic backbone and side chains facilitating linkage to the surfaces of nanoparticles was used to coat hydrophobic Fe3O4nanoparticles. Such nanoparticles, (4–11 nm), were coated by coordinate bonding and hydrophobic interactions with a hydrophilic poly(amino acid) derivative, poly(2-hydroxyethyl aspartamide). This is a new method for the transfer of hydrophobic nanoparticles from organic solvents into water. The biocompatible poly(amino acid)-coated Fe3O4nanoparticles were smaller than 30 nm in aqueous solutions, extremely stable, and maintained their stability even after several lyophilizations. The poly(amino acid)-coated nanoparticles showed no cytotoxicity, good saturation magnetization, and high T2 relaxivity coefficients (r2 values). The poly(amino acid)-coated Fe3O4nanoparticles demonstrate strong potential in bioapplications such as magnetic resonance imaging (MRI).
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