Abstract
The major problems in drug delivery to specific diseased sites possess drug-resistance, drug-toxicity, biological barriers and non-specificity to the target-cells observed among patients worldwide. To overcome these barriers, the biodegradable poly alkyl cyanoacrylate (PACA) nanocarriers have been used, while a core made up of PACA is functionalized with biologically active ligands such as cargos, biotin and antibody for enabling specific targeting, and stabilized with outer polyethylene glycol or surfactants in combating cancer, neurodegenerative and infectious diseases. The review demonstrates mainly the synthesis, functionalizations and the biomedical applications of PACA nanoparticles against various diseases to consider them as potent delivery vehicle.
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