Poly (2-hydroxyethylmethacrylate -co-methylmethacrylate)/Lignocaine Contact Lens Preparation, Characterization, and in vitro Release Dynamic.

Taieb Aouak,Abdel-Basit Al-Odayni,Idriss Bedja,Wassem Sharaf Saeed,Nawaf M Al-Hafi,Abdulaziz Ali Alghamdi

doi:10.3390/polym11050917

Abstract

2-hydroxyethyl methacrylate, methylmethacrylate, ethylene glycol dimethyl methacrylate, and lignocaine (drug) were mixed together and the monomers were copolymerized at 60 °C through a free radical polymerization in the presence of α,α′-Azoisobutyronitrile in tetrahydrofuran. A series of copolymer/drug composites with different monoacrylate monomer compositions were prepared by solvent evaporation and characterized by different methods such as nuclear magnetic resonance, differential scanning calorimetry, Fourier transform infrared, X-ray diffraction, and mechanical and optical testing. The water content in the copolymers and the cell viability test on the samples were also examined in this investigation. The results of the analyses of the properties of this drug-carrier system are promising, indicating that this material may be a potential candidate for contact lens applications. The release dynamic of this medication from the prepared drug-carrier systems was investigated in neutral pH media. The results obtained revealed that the diffusion of lignocaine through the copolymer matrix obeys the Fick model and the dynamic release can be easily controlled by the methyl methacrylate content in the copolymer.

Highlights

Contact lenses are a commonly used device that corrects refraction and protects the ocular surface.Recently, there has been increased interest in delivering drugs through contact lenses, because common eye drops are inefficient in delivering drugs that penetrate the cornea and reach the ocular tissue [1,2]; only 5% of the applied drug penetrates the cornea after eye drop use
The pure LIG drug was extracted by evaporating water at 40 ◦ C under reduced pressure. 1, 1-Diphenyl-2-picryl-hydrazyl (DPPH), Dulbecco’s modified Eagle’s medium (DMEM), fetal bovine serum (FBS), and ascorbic acid were all provided by Sigma Aldrich
The spectra belonging to the PHEMMA/LIG systems did not reveal any sharp signals indicative of the crystallinity of this system, indicating that these composites have amorphous structures. These results suggested that LIG was uniformly distributed in the copolymer matrix in its molecular state, as consistent with the results obtained by Fourier transform infrared (FTIR)

Summary

Introduction

There has been increased interest in delivering drugs through contact lenses, because common eye drops are inefficient in delivering drugs that penetrate the cornea and reach the ocular tissue [1,2]; only 5% of the applied drug penetrates the cornea after eye drop use. The remaining drug reaches the bloodstream through the lacrimal sac and nasolacrimal duct [4]. This shows that the use of drops as a drug delivery system limits the efficacy of the therapeutic system and wide-angle glaucoma treatments, such as the beta-blocker Timolol, have a deleterious effect on the heart [5]. The drug is released from the contact lens in a short period of time

Methods

Results

Conclusion