Abstract
Pralidoxime chloride (PAM-Cl)-loaded poly (2-hydroxyethyl methacrylate) (PHEMA)-based hydrogels were prepared by bulk copolymerization of 2-hydroxyethyl methacrylate (HEMA) with different mol fractions (0.02–0.10) of trimethylsilyl methacrylate. Characterization of the gels was done by dynamic swelling measurements. It was found that copolymerization does not alter the swelling mechanism of PHEMA and it essentially remains Fickian in nature. In vitro drug-release studies show the increase in release time from 6 to 12 h on incorporation of a 0.1 mol fraction of trimethylsilyl methacrylate on the PHEMA backbone. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 267–270, 1997
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