Abstract
Poliovirus antibody response in γG, γA, and γM classes of immunoglobulins in serum was determined after immunization with inactivated (Salk) polio vaccine in children with acute lymphocytic leukemia, in healthy children (control), and in children with solid tumors: Ewing's, Wilms', and osteogenic sarcoma. Serum response in healthy children and in children with solid tumors was characterized by the regular appearance of high levels of γM and γG and occasionally of γA poliovirus antibody. Primary immunization in children with acute leukemia elicited low or undetectable γG and no γA poliovirus antibody response. Most significantly, however, γM poliovirus antibody response was conspicuously absent. Reimmunization with inactivated vaccine in patients with acute leukemia manifested a 2- to 3-fold rise in the pre-existing γG antibody levels. Although reimmunization resulted consistently in the reappearance of γM poliovirus antibody in previously immunized control subjects, patients with acute leukemia failed to elicit any γM antibody response.
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