Abstract
To build a mitotic spindle, the yeast spindle pole body (SPB) must penetrate the nuclear envelope (NE), which never breaks down in yeast. Unlike the budding yeast Saccharomyces cerevisiae, whose SPB is always in the NE, the SPB of Schizosaccharomyces pombe is cytoplasmic during interphase and only enters the NE during mitosis. West et al. now implicate the cut11 gene in this process1xcut11+: a gene required for cell cycle-dependent spindle pole body anchoring in the nuclear envelope and bipolar spindle formation in Schizosaccharomyces pombe. West, R.R., Vaisberg, E.V., Ding, R., Nurse, P., and McIntosh, J.R. Mol. Biol. Cell. 1998; 9: 2839–2855Crossref | PubMedSee all
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