Polarographic study of some derivatives of 3H-1,5-benzodiazepine

Abstract

Electroreduction of compounds I–VI (Table 1) on the DME is described. The investigations were made in mixtures of Britton-Robinson buffers and DMF (3:2). Two main reduction waves were obtained which correspond to the consecutive reduction of 4,5- and 1,2-double bonds in the diazepine ring to corresponding hydro derivatives. The second reduction waves in acid media for 4-pyridyl derivatives were disturbed by the evolution of hydrogen catalysed by the adsorption of the first stage reduction product. For derivatives containing 3-pyridyl substituents the second wave was practically not observed. The reduction mechanism of the compounds investigated is proposed and discussed.