Polarographic study of 1-methyl-5- o-chloropheyl-7- ethyl-1,2-dihydro-3H-thieno[2,3-e],[1,4]-diazepin-2-one (clotiazepam)

Abstract

The electroeducation of 1-methyl-5- o-chlorphenyl-7-ethyl-1,2-dihydro-3H-thieno[2,3-e],[1,4]-diazepin-2-one (Clotiazepam) is investigated by different polarographic techniques. The electrochemical reactioninvolves a 2-electron exchange in both acidic and alkaline media. The reduction process is irreversible and the current is diffusion-controlled. With differential pulse polarography, the linear response range is 6.5 × 10 -7— 1.10 × 10 −5 M, with a relative standard deviationof 1.2% at the 2.6 × 10 −6 M level. The method is applied to the determinationof Clotiazepam in tablets after simple dissolution in 0.1 M sulphuric acid.