Abstract
Propranolol was reacted with nitric acid to give nitropropranolol and was then measured in Britton–Robinson solutions in the pH range 2.0–12.0 by differential-pulse polarography. Nitropropranolol gave rise to a well-resolved differential-pulse polarographic peak at pH 2.0. A linear calibration graph in the range 5.0×10 −7–5.0×10 −5 M and a detection limit of 5 nM was obtained. The relative standard deviation was 1.95% ( n=10) at 5×10 −6 M. The effect of common exceipient on the peak height was evaluated. The method was applied for the determination of the drug in the tablet dosage form.
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