Abstract
Polarographic and colorimetric methods for analysis of cyclophosphamide and its dosage forms were investigated. Both methods are based on the reaction of cyclophosphamide with nitrous acid. A single cathodic diffusion-controlled wave was used for dc polarographic determination of cyclophosphamide, with an accuracy of 99.98 +/- 1.09%. The wave was well defined and irreversible. By differential pulse polarographic analysis, as little as 10 ppm cyclophosphamide was determined; overall accuracy at 10-60 ppm was 100.16 +/- 0.99%. The linear relationship between absorbance for the lemon-yellow nitroso derivative and the concentration of cyclophosphamide was further used in colorimetric analysis; overall accuracy was 100.2 +/- 0.99%.
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