Polarized superlocalization in magnetic nanoparticle hyperthermia

Abstract

Magnetic hyperthermia is an adjuvant therapy for cancer where injected magnetic nanoparticles are used to transfer energy from the time-dependent applied magnetic field into the surrounding medium. Its main importance is to be able to increase the temperature of the human body locally. This localization can be further increased by using a combination of static and alternating external magnetic fields. For example, if the static field is inhomogeneous and the alternating field is oscillating then the energy transfer and consequently, the heat generation is non-vanishing only where the gradient field is zero, which results in superlocalization. Our goal here is to study theoretically and experimentally whether the perpendicular or parallel combination of static and oscillating fields produce a better superlocalization. A considerable polarization effect in superlocalization for small frequencies and large field strengths is found, which is of great importance for practical applications.