Abstract
Despite long-held theories to the contrary, bacteria have proven to be polar organisms. According to Scott et al. [ 1 Scott M.E. et al. Directed polar secretion of protease from single cells of Vibrio cholerae via the type II secretion pathway. Proc. Natl. Acad. Sci. U. S. A. 2001; 98: 13978-13983 Crossref PubMed Scopus (76) Google Scholar ], not only do they elaborate polar appendages such as flagella and adhesive pili, they also secrete enzymes in a targeted, polar fashion. The terminal branch of the type II secretion pathway, also called the general secretory pathway, is responsible for secreting virulence factors from diverse Gram-negative pathogens.
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