Abstract
We made a tissue phantom with double-peak particle size distribution, which has polystyrene particles of cell nuclear size and mitochondrial size, and measured the spectrum from the tissue phantom using a single optical fiber. In this paper we investigate the characterization method for the tissue phantom with double-peak particle size distribution by comparing the measured spectra with the calculated ones using the Monte Carlo (MC) method. It is first shown that the Mie phase function characterizes better than the Henyey-Greenstein (H-G) phase function in MC calculation. Next, we compare the measurement spectra with those obtained by modeling as single-peak, conventional modeling for particle size distribution, and for double-peak particle size distribution. The single-peak modeling is found to cause considerable error for the tissue phantom with double-peak particle size distribution, which seems to simulate a biological tissue. We suggest that if one simulates the particle size distribution of a biological tissue by conventional modeling, the accuracy of estimation will be lower.
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