Abstract
Feelin' groovy: An emissive furan-containing nucleoside, which serves as a minimally invasive isomorphic thymine analogue, was used to estimate groove polarity in DNA. By determining the associated microscopic solvent-polarity value ET(30) as shown in the figure, a rather apolar environment was detected. Such studies are likely to shed new light on fundamentally important questions regarding biopolymeric microenvironments.
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