Abstract
Vanillylformamide [systematic name: N-(4-hydroxy-3-methoxybenzyl)formamide], C9H11NO3, (II), has been synthesized from vanillylamine hydrochloride and studied by single-crystal X-ray diffraction. Compound (II) and the well known biologically active eugenol compound (I) can be considered to be `isosteres' of each other, since they share comparable molecular shape and volume. The product (II) crystallizes in the space group P1. In the crystal, the vanillylformamide molecules are linked mainly by N—H...O, O—H...O and Csp 2—H...O hydrogen bonds, forming infinite two-dimensional polar sheets. These two-dimensional layers pack in a parallel fashion, constructing a polar three-dimensional network. Except for van der Waals forces and weak Csp 3—H...O hydrogen bonds, there are no significant intermolecular interactions between the layers. A Cambridge Structural Database search revealed that vanillylamide-related crystals are scarce.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
