Poisson-distributed noise induces cortical γ-activity: explanation of γ-enhancement by anaesthetics ketamine and propofol

Abstract

Additive noise is known to affect the stability of nonlinear systems. To understand better the role of additive noise in neural systems, we investigate the impact of additive noise on a random neural network of excitatory and inhibitory neurons. Here we hypothesize that the noise originates from the ascending reticular activating system. Coherence resonance in the γ-frequency range emerges for intermediate noise levels while the network exhibits non-coherent activity at low and high noise levels. The analytical study of a corresponding mean-field model system explains the resonance effect by a noise-induced phase transition via a saddle-node bifurcation. An analytical study of the linear mean-field systems response to additive noise reveals that the coherent state exhibits a quasi-cycle in the γ-frequency range whose spectral properties are tuned by the additive noise. To illustrate the importance of the work, we show that the quasi-cycle explains γ-enhancement under impact of the anaesthetics ketamine and propofol as a destabilizing effect of the coherent state.