Point Process Filtering Estimates of Branching Rate for Neural Dendritic Morphology Generation.

Abstract

Current parametric approaches to dendritic morphology generation are limited in their ability to replicate realistic branching. A non-parametric approach applying a point process filter and the expectation-maximization algorithm offers a data-based solution that estimates the dendritic branching rate based on observations of bifurcation events in real neurons. Point processes can then be simulated using this branching rate estimate to indicate when a generated morphology should branch. Morphologies generated using this technique match both basic and emergent property distributions of the real neurons used as input into the algorithm. Further refinement of branching angles will allow for a flexible tool to generate realistic morphologies of a variety of neuronal stereotypes.