Abstract
Aim:The hypothalamic–pituitary–adrenal axis is involved in maintaining homeostasis by engaging with the parasympathetic nervous system. During the process of disease affliction, this relationship is disturbed and there is an imbalance driven response observed.Materials & methods:By monitoring the two key components involved in these pathways, cortisol and TNF-α, the manifestations of chronic stress on the body’s homeostasis can be evaluated in a comprehensive manner. This work highlights the development of an electrochemical detection system for the two biomarkers through human sweat.Results:Limit of detection and dynamic ranges are 1 ng/ml, 1–200 ng/ml for cortisol and 1 pg/ml, 1–1000 pg/ml for TNF-α.Conclusion:This wearable system is designed to be a point of use, chronic disease self-monitoring and management platform.
Highlights
COMSOL Multiphysics R simulations highlight the optimal electrode design and the wicking capabilities of the hydrophilic nanoporous membrane. This is key for sweat based detection where passive sweating is used as a mode of sample collection
This work uses a novel, electrochemical wearable platform to offer enhanced sensitivity and improved sensor stability to map the endocrine-inflammatory relationship toward advancement of chronic disease diagnosis and management
Summary
The hypothalamic–pituitary–adrenal axis is involved in maintaining homeostasis by engaging with the parasympathetic nervous system. The goal of this work is demonstration of a biosensor that is capable of tracking these molecules in human sweat
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