Pogonatherumol, a Novel Highly Oxygenated Norsesquiterpene with Flavone C-Glycosides from Pogonatherum crinitum

Lin Ni,He-Shan Wang,Hui-You Xu,Wei Huang

doi:10.1155/2018/5029610

Abstract

A novel highly oxygenated norsesquiterpene, pogonatherumol (1), with two known flavone C-glycosides (2-3), was isolated from Pogonatherum crinitum. The structure of the new compound was illuminated based on its spectroscopic data and X-ray analysis. Compounds 1 and 3 inhibited NO production in the mouse peritoneal macrophage (64.5 ± 7.2% and 61.6 ± 5.8%, respectively, at a concentration of 50 μM). The three compounds were inactive when tested against two human cancer cell lines (IC50 values > 50 μM).

Highlights

Pogonatherum crinitum, is one of the species in the genus Pogonatherum of Gramineae family, which has been used as a natural medicine in Chinese folk [1], for treatment of diabetes, urinary tract infection, jaundice hepatitis, and nephritis [2,3,4,5]
E ethyl acetate segment (113.2 g) was dissolved in water and subjected to passage over polyamide eluting with H2O and 50% EtOH-H2O (v/v), successively. e 50% EtOH-water extract was passed over Column chromatography (CC) on silica gel eluting with CH2Cl2-MeOH (15 :1–1 :1) to afford 8 segments (B1–B8)
Two known C-glycosides, schaftoside (2) [11] and isoschaftoside (3) [12], were identified by comparing their ESIMS and 1H and 13C NMR data with those reported in the literature

Summary

Introduction

Pogonatherum crinitum, is one of the species in the genus Pogonatherum of Gramineae family, which has been used as a natural medicine in Chinese folk [1], for treatment of diabetes, urinary tract infection, jaundice hepatitis, and nephritis [2,3,4,5]. In order to discover structurally and biologically interesting compounds from P. crinitum, a novel highly oxygenated norsesquiterpene, pogonatherumol (1) with two known flavone C-glycosides was investigated (Figure 1). The isolation and structural characterization of the compounds and their biological activities are reported in this paper.

Results

Conclusion