Abstract

Background Although podoplanin (PDPN) has been recognized as a lymphatic endothelial marker, the expression is also recognized in healthy and diseased human skin, such as sebaceous gland, hair follicles, wound, and psoriatic epidermis. However, the precise function has not been fully elucidated. Objective This study was carried out to verify PDPN-function in normal human epidermal keratinocytes (HEK), focusing on cell adhesion and differentiation. Methods Cell adhesion and differentiation of HEK were analyzed in both conditions of PDPN-overexpression and silencing using adenoviral vector.

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