Year-end Sale % OFF 
Abstract
Podophyllotoxin (PPT) exhibits the various bioactive activities in the traditional treatment of many diseases. As the important ethnomedicine resources of China, PPT produced by Juniperus rigida could become a promising alternative sources of Podophyllum hexandrum, which is endangered by overcollection. However, it is unclear whether the genetic diversity of J. rigida is associated with its PPT contents for the different regions. To search the characteristic of J. rigida with high PPT contents and genetic diversities, the superior genotypes of J. rigida were researched by combing PPT profiles with SRAP molecular markers. The results showed that the higher contents of PPT of J. rigida were found in YJ (Shaanxi, 189.18 mg/g) and XDC (Hebei, 184.81 mg/g) and the lower in JHX (Jilin, 71.90 mg/g), CBS (Jilin, 94.92 mg/g) and LYM (Liaoning, 71.11 mg/g). The higher genetic diversity was found in two varieties of J. rigida (i.e., CBS (Jilin) and LYM (Liaoning)). To explore the relationship between the PPT profiles and genetic diversity, J. rigida from ten regions were divided into the same two groups distinguished by PPT contents and SRAP molecular marker, which were PPT contents in the Loess Plateau of China higher than that in the northeast of China. Specially, the contents of PPT exhibited an extremely significant positive correlation with geographic distance/genetic distance. These findings would not only provide a scientific basis for the selecting powerful source of high PPT genotypes of J. rigida in breeding research, but also made J. rigida a promising alternative source of PPT for the pharmaceutical industry.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
