Abstract

VP-16-213 (Etoposide), a semi-synthetic derivative of podophyllotoxin, has been shown to be an effective antitumor agent in the treatment of lung cancer, a variety of leukemias, and other solid tumors. Although VP-16-213 and podophyllotoxin possess similar chemical structures, each drug expresses different biological properties. Structure-activity relationship studies have identified some of the chemical sites responsible for each of their biological properties and has offered insights into their respective mechanisms of action.

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