Podocyte Foot Process Effacement in Postreperfusion Allograft Biopsies Correlates with Early Recurrence of Proteinuria in Focal Segmental Glomerulosclerosis

Abstract

Background Focal segmental glomerulosclerosis (FSGS) is a relatively prevalent glomerular disorder that often progresses to end-stage renal disease. 30 to 80% of kidney transplant (KT) recipients with FSGS will experience recurrence characterized by proteinuria and podocyte damage. We hypothesized the degree of podocyte foot process (FP) effacement in post-reperfusion transplant biopsies can be used to predict the development of clinical recurrence of FSGS.