POCl3‐Mediated Reaction: A New Entry to Polysubstituted 2‐Pyridones via Self‐condensation of β‐Keto Amides

Abstract

Synthesis of polysubstituted 2‐pyridones and their analogues from β‐keto amides via self‐condensation cyclization is described. Notable advantages include mild reaction conditions, reduced synthetic steps, high yields, and a readily available starting materials. Further mechanistic studies suggest that the transformation proceeds through self‐condensation, intramolecular nucleophilic cyclization, and elimination.