Abstract
The use of ultrasound in medicine has quickly evolved in the last decade as a therapeutic modality and means to treat disease independently or in combination with other therapeutic regimes such as chemotherapy. The interaction of ultrasonic waves with soft mammalian tissues has the innate impact of enhancing tissue permeability to therapeutics, increasing local blood flow at low‐acoustic powers, and causing tissue necrosis and cell death at higher‐energy levels. We have developed multiple pocket‐sized (4×2×1 in.) lithium battery powered therapeutic ultrasound units based off of our novel ultra‐efficient electrical amplifier design that produces acoustic energies for low‐ and high‐power applications (1–130 W). The portable ultrasound technology has been used in our laboratory to enhance ten‐fold the delivery and efficacy of convection enhanced drug delivery to treat brain gliomas in vitro and in vivo. Our clinical collaborates at Weill Cornell Medical Hospital use our devices at high powers to non‐invasively cauterize veins as a novel method of varicose vein treatment. Our clinical collaborators provide new avenues of ultrasound research and critical user feedback on the technology to aid refinements in its implementation in hand‐held acoustic applications.
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