PO56 Prevalence of early menopause/secondary amenorrhea in premenopausal women diagnosed with early breast cancer who received adjuvant or neoadjuvant treatment based on docetaxel

Abstract

undergoing BCT in the Indian scenario hypothesizing that for carefully selected patients BCT is a viable treatment option. Methods: In a retrospective review of prospectively maintained computerized database of 2500 operated breast cancer patients a total of 355 patients undergoing BCT were identified. Patients with age less than 40 years at presentation, unilateral lesion and known receptor and Her 2 status were included. Patients who received NACT and who did not complete planned RT were excluded. Results: 136 patients under 40 years of age had BCT. These patients were divided into TNBC and Non TNBC groups. TNBC patients constituted 54% of patients. Mean age (34.7 vs 35.1), tumour size (3.1 vs 2.6), stage at presentation (Stage I 15% vs 20%, Stage II 65% vs 75%, Stage III 20% vs 5%), pathological nodal status (pN0 53% vs 62%) and average LN dissected (11.5 vs 12.5) were comparable in the two groups. Standard lumpectomy was offered to all patients whereas Quadrantectomy (14% vs 6%) and Oncoplasty with volume replacement (4 patients vs. 2 patients) was used in both groups. At a mean follow up of 36 months Loco regional recurrence was 2.74% vs. 1.6% and Distant metastasis 6.8% vs. 11.1% in TNBC and non-TNBC group respectively. Discussion: Results of the present study indicate feasibility and safety of BCT in young TNBC patients. Hence young age at presentation associated with TNBC is not a contraindication for BCT provided they fulfill the standard criteria for BCT.