PO395 YEAR SURVIVAL WITH GLIOBLASTOMA: A NATIONAL PERSPECTIVE

Abstract

INTRODUCTION: Median life expectancy of patients with Glioblastoma is 6 months in England for all therapies. Most studies of long term survivors of Glioblastoma include small numbers of patients from a single institution. METHOD: A Population based study using data linkage between the National Cancer Registration Service and Hospital Episode Statistics for England was performed to identify patients who have survived more than 5 years after a histological diagnosis of Glioblastoma from January 2000 to June 2009. RESULTS: 17,786 patients were identified with Glioblastoma in this 10 year period. Data quality was variable in the cohort but there appear to be at least 96 patients who have survived 5 years from diagnosis. 54% were women. The cohort are younger than the national profile, with 67% aged less than 50 years. 70% of patients overall had debulking surgery and chemoradiotherapy. Multiple operations were more common, 55% of patients were recorded as having more than one procedure, and one patient had 6 craniotomies during the course of their treatment. CONCLUSION: There is a cohort of patients that survive for more than 5 years. This cohort is younger, and has more aggressive treatment than is seen overall. Could some of these patients represent a cure? Further investigation into this group could lead to promising avenues for treatment. Aggressive treatment in a very selective cohort can lead to extended survival for patients with Glioblastoma.