PO39 Presentation Time: 4:45 PM: Medical Comorbidities in Cervical Cancer Treated with External Beam Radiotherapy and Brachytherapy: A Single Institutional Study

Abstract

<h3>Purpose</h3> There are limited studies on the association between medical comorbidities and cervical cancer. This study aimed to elucidate the incidence, spectrum, and impact of medical comorbidities on clinical outcomes in patients with cervical cancer treated by external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT). <h3>Materials and Methods</h3> From October 2015 to September 2018, data of 100 cervical cancer patients were collected from our institute. These patients were treated with EBRT with concurrent chemotherapy followed by brachytherapy. The following important information was extracted: age, disease stage, comorbidities, treatment, follow-up, disease status, and radiation toxicities. <h3>Result</h3> Median age of patients with and without comorbidities were 52.5 and 47.5years. A total of 39 medical disorders were found in 28 patients. The distribution as per comorbidities was as follows: Hypertension, 17 patients; diabetes mellitus, 7 patients; hypothyroidism, 3 patients; cardiovascular disease, 3 patients, and others 9 patients. Out of 28 patients with comorbidities, 10 patients were stage IIIB, 10 were IIB, 4 were stage IB2 and the rest were other stages. Of them, 24 patients completed the prescribed treatment, and the remaining 4 patients did not complete ICBT. Median survival among patients with and without comorbidities was 28 and 26.5 months respectively. The 3-year overall survival rate in patients with and without comorbidities was 84.6% vs 89% (p-value, 0.56). There was no correlation between comorbidity and late radiation morbidity. <h3>Conclusion</h3> Results of our study show that the incidence of medical comorbidities can be as high as 28% in cervical cancer patients. Hypertension and diabetes are the commonest comorbidities associated with cervical cancer. There was no impact of comorbidities on clinical outcomes in cervical cancer patients.