PO389 ALDH2 IS A POSITIVE REGULATOR OF ADIPOCYTE DIFFERENTIATION

Abstract

both serum ferritin and aminotransferase level as well as C-peptide level at baseline. Biochemical parameters also measured at baseline. To characterize serum ferritin level variable according to metabolic traits and liver function, we analyzed liver function and beta cell function, respectively. To compensate the gender differences, each subject was analyzed separately by sex. Male subjects were categorized into two groups, Group I (abnormal liver function test group) or Group II (normal liver function group) based on aminotransferase level. Result: Of the 108 subjects (67 men and 41 women), male subjects (n=67) had significantly higher ferritin level (202.6ng/ml vs 87.6ng/ml, p= 0.001) and hemoglobin (Hb) level (13.5g/dl vs 12.2g/dl, p< 0.001) than women (n=41) subjects. However total cholesterol level was lower inmale thanwomen subjects. (158.4mg/dl vs 183.9mg/dl, p= 0.005) Subjects with higher aminotransferase level than 40IU/L were defined Group I (n=17). Group I showed significantly higher serum ferritin level (309.8ng/ml vs 166.1ng/ml, p= 0.01) and basal C-peptide level (1.6ng/ml vs 2.7ng/ml, P = 0.025) than Group II. Multiple linear regression analyses showed that basal C-peptide level (p= 0.005) and total cholesterol level (p =0.015) were independently associated with serum ferritin level, only in women subjects. Also, a significant positive correlation was observed serum ferritin level and basal C-peptide level (r = 0.409, P = 0.012) and waist circumference(r = 0.399, P =0.016) in women subjects. Conclusion: Serum ferritin was significantly increased in male subjects with abnormal liver function and insulin resistance. In women subjects, serum ferritin level was positively associated with metabolic syndrome components, such as waist circumference and insulin resistance.