Abstract
Vagus nerve stimulation (VNS) has been shown to modulate cognitive activity with immediate effects on arousal capacity, decisional tasks such as response selection, improvement of associative memory and working memory. These effects are probably produced by increasing activity in the locus ceruleous-norepinephrine (LC-NA) pathway. The P300 evoked potential, reflects the neural activity of cognitive networks related to neuromodulatory phasic activity of the LC-NA system. The amplitude of this potential is related to selective attention and its latency to the time required to categorise the presented stimuli as relevant. We wanted to address the modulatory effects of a single application of auricular transcutaneal VNS (atVNS) on the P300 parameters and the Reaction Time (RT) and to determine the duration of these changes.
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