Abstract
Spinal cord stimulation (SCS) is an established treatment for chronic neuropathic pain1. Besides paresthesia-inducing conventional (con-SCS), paresthesia-free (i.e., sub-perception) SCS paradigms have also been developed, but they exhibit a longer duration until analgesia, which may complicate clinical device programming2. In contrast, Fast-Acting-Sub-Perception-Threshold-SCS (FAST-SCS) is a novel sub-perception paradigm that induces a rapid onset of analgesia3. We assessed 4 variations of FAST-SCS in a rat model of chronic neuropathic pain to evaluate the effect of stimulation amplitude (at 40 or 60% motor threshold (MT)) and the effect of active (FAST-A-SCS) or pseudo-passive (FAST-P-SCS) charge balance.
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