Abstract
In patients with chronic discogenic low back pain (CDLBP), the intervertebral disc degenerates. Subsequent development of inflammation and nerve ingrowth causes chronic pain 1–3. For CDLBP patients, conventional pain medication is often not sufficient. Neuromodulation has shown to be an effective method for reducing pain4. To test novel stimulation parameters, appropriate animal models for DLBP compatible with neuromodulation must be developed. Here, we investigate the applicability of a CDLBP animal model for studying the effectivity and mechanisms of neuromodulation5.
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