PO-1024 The Importance Of Proinflamatory Cytokine’s In Immune Response In Mycoplasma Pneumoniae Infection In Children With Bronhopulmonary Affection

Abstract

<h3>Aims</h3> Our study was to evaluate proinflammatory cytokine’s (IL-2) interaction with humoral immunity in children with <i>Mycoplasma pneumoniae </i>lower respiratory tract infection. <h3>Methods</h3> The study group included 20 children, aged 5 months – 7 years, with pneumonia and wheezing induced by <i>Mycoplasma pneumoniae </i>infection. The diagnosis of <i>M.pneumoniae</i> was based on clinical, radiological and on the immunological determinations of specific antibodies in diagnosis titers. Levels of IgA, IgM, IgG, IL-2 were determined in serum samples obtained from all children and were tested by <i>ELISA</i>. <h3>Results</h3> IL-2 levels in children with <i>Mycoplasma</i>-positive bronchopulmonary disease was 36,51 ± 2,26 pg/ml (variation 20,0–100,85 pg/ml) and it is higher, than in healthy children (variation 2,44–7,2 pg/ml) pg/ml. In study group average level of IgA was 0,96 ± 0,13 g/l did not differ from levels of IgA in healthy children (IgA 0,9 ± 0,04 g/l). But level of serum IgM was higher (p &lt; 0,05) in <i>Mp</i>-positive group (1,8 ± 0,16 g/l) in comparison with levels of IgM in healthy children (1,2 ± 0,1 g/l). In study group level of IgG was higher (9,47 ± 0,67 g/l; p &lt; 0,05) in comparison with age norms (7,5 ± 0,1 g/l). <h3>Conclusion</h3> Inflammatory processes in children with <i>Mycoplasma pneumoniae</i> infection are characterised by hyper production of IL-2, and they are associated with high serum levels of IgM, IgG.