Abstract
Cerebellar pathways are increasingly being targeted using both non-invasive and invasive neurostimulation-based approaches for the treatment of neurologic disease. Our recently-completed Phase I trial of deep brain stimulation (DBS) of the dentato-thalamo-cortical (DTC) pathway to enhance chronic, post-stroke motor rehabilitation has demonstrated promise for reducing impairment. As part of that study, we were able to characterize acute electrophysiological changes associated with cerebellar dentate nucleus (DN) DBS in relation to motor behavior and examined the spatiotemporal pattern of cerebral cortical changes using scalp electroencephalography (EEG).
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