Abstract
An association between the induction of neuronal plasticity and effects of Vagal Nerve Stimulation (VNS) on Drug-Resistant Epilepsy (DRE) has been hypothesized but not fully demonstrated in humans.1 Long-term plasticity is the neurophysiological correlate of changes in the brain network.2 Functional connectivity (Fc) describes statistical dependency patterns of different electrodes in selected time series through different metrics:3 among them, Phase Lag Index (PLI) quantifies the asymmetry of distribution of phase differences between two signals, represents the synchronization of the EEG signal4 and is poorly affected by interference from the use of a scalp signal.
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