PO-0475 The Effect Of Co2-insufflation On Cerebral Oxygenation In Thoracoscopic Repair Of Esophageal Atresia In Neonates

Abstract

Aim of the study Infants undergoing neonatal surgery for thoracoscopic esophageal atresia repair are at high risk of adverse neurodevelopmental outcomes. Increasing concerns have been raised about the incidence of perioperative brain injury, this is suggested to be due to haemodynamic instability and hypoxia perioperatively. We evaluated the effects of CO2-insufflation on regional cerebral oxygen saturation (rScO 2 ) during thoracoscopic esophageal atresia repair. Methods Observational study of 20 neonates undergoing thoracoscopic esophageal atresia repair. During surgery mean blood pressure (MABP), FiO 2 , arterial saturation and the cerebral oxygen saturation (rScO 2 ) were continuously monitored. Four periods of 10 min were selected: (T=0) during anaesthesia, (T=1 and T=2) during CO 2 -insufflation and (T=3) after desufflation. Main results Complete registration was obtained in 14 neonates (median GA 36.9 [30.6–41.9], birth weight 2358 g [1395–4490]) and were included. After CO 2 -insufflation the FiO 2 increased from 41% to 58%, whilst the saturation decreased from 96.3% to 92.5%(p The arterial pCO 2 (mmHg) changed from 47 ± 6.9 to 56 ± 13(p 2 -insufflation and remained stable at the end of insufflation and after desufflation. The rScO 2 did not change after CO 2 -insufflation or desufflation. Conclusion Intrathoracic CO 2 -insufflation causes a decrease in arterial saturation and an increase in arterial pCO 2 . However, more importantly these changes did not result in significant fluctuations in cerebral oxygenation throughout the procedure. The insufflation of CO 2 with 5 mmHg during thoracoscopy seems to be safe in neonates, since the cerebral oxygenation was preserved during the procedure.