Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is standard of care treatment for moderate to severe Parkinson’s disease. However, optimizing the therapeutic benefit of DBS can, in some cases, be complicated by the occurrence of side effects that are attributed to current spread outside of the target region. Modeling studies have suggested non-symmetric waveforms may result in preferential activation of neural elements and potentially increase DBS’ therapeutic window [1]. To date, however, data demonstrating the physiological effects of alternative waveform morphologies in human patients has been limited.
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