PO-0066 Circulating Oxidised Ldl And Insulin Resistance Among Obese School Students

Abstract

Circulating oxidised LDL (ox-LDL) is associated with obesity, insulin resistance (HOMA), metabolic syndrome, and cardiovascular disease in adults. Little is known about relations in children. Aim To assess association of ox-LDL with fat distribution and insulin resistance in a group of obese Egyptian children. Methods Study is cross-sectional consisted of 68 obese children, mean age 9.96 ± 1.32. Each underwent a complete physical examination; blood pressure (SBP, DBP) and anthropometric measurements (weight, height, BMI; waist, hip circumferences, waist/hip ratio), biochemical tests of fasting blood glucose (FBS), insulin levels; lipid profile (TC, LDL, HDL, TG) and ox-LDL; calculated HOMA. Sample was classified according to waist/hip ratio into: group I with and groupII without central obesity. Results ox-LDL showed significant positive correlation with LDL and TC in all groups of obesity. After adjustment for age and sex, significant positive correlation was detected between ox-LDL with SBP, DBP, TC, LDL, insulin, and HOMA in groupII and with TC and FBS in groupI. Insignificant association was detected between ox-LDL and other anthropometric parameters including BMI in any group of obese children (p > 0.05). Conclusions ox-LDL, as a marker of oxidative stress is not correlated with BMI among all studied obese children (aged 6–12 years). Increased oxidative stress has causal effects on insulin resistance in obese children without central obesity and on fasting blood sugar in those with central obesity. These findings emphasise the importance of obesity during childhood and suggest that the metabolic complications of obesity and body fat distribution are detectable early in life.