PO-686-06 A RANDOMIZED NONINFERIORITY STUDY OF THE TYRX-A ANTIBACTERIAL ENVELOPE ALONE VERSUS ENVELOPE PLUS INTRAOPERATIVE ANTIBACTERIAL IRRIGATION AND POSTOPERATIVE ORAL ANTIBIOTICS TO PREVENT CARDIAC IMPLANTABLE ELECTRONIC DEVICE INFECTIONS IN HIGH-RISK PATIENTS

Abstract

CIED infection has a high mortality rate. The WRAP-IT trial showed reduced infection using the TYRX-A envelope. The PADIT trial found no benefit to intensified antibiotic prophylaxis without TYRX-a. This is the first evaluation to test both.