Abstract
High-protein diet (HPD) has been advocated as a means of weight loss and to prevent the obesity-related metabolic sequelae, partially because it can improve insulin sensitivity. However, recent studies reveal that the dietary protein can drive atherosclerosis and lesion complexity. It remains controversial whether dietary protein exerts cardiovascular risk. Activation of NLRP3 inflammasome can enhance the pathogenesis of atrial fibrillation (AF). The role of Absent-in-Melanoma 2 (AIM2) inflammasome in AF development remains elusive.
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