Abstract

Atrial Fibrillation (AF) is an independent risk factor for incident dementia. Overt stroke, microembolism and microbleeds are among the main mechanisms linking this arrhythmia and cognitive dysfunction. Cerebral hypoperfusion related to beat-to-beat blood flow variation during AF can also explain the occurrence of dementia or mild cognitive impairment, as rhythm control strategies were shown to reduce its incidence. However, data regarding brain metabolism patterns in patients with AF are still scarce.

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