PO-257 The immunoreactivity of patients with cervical cancer on the background of extracorporeal immunopharmacotherapy (EIPHT)

Abstract

IntroductionThe aim of the study was to study the state of cellular and humoral factors of immunity of cervical cancer patients on the background of using extracorporeal immunopharmacotherapy.Material and methods136 patients with cervical cancer T2-3N0-1M0 stages. With cervical cancer IIA, the stage of the disease was observed in 18.7% of cases, IIB - in 20.9%, IIIA - in 16.0% and IIIB stage - in 44.4% of cases. The largest part of the patients was female cervical cancer at stage IIIB. Depending on the methods of therapy in the complex treatment: group 1–36 patients with cervical cancer before treatment; 46 patients with cervical cancer who received EIPHT with thymalin; group 3–54 patients with cervical cancer who did not receive EIPHT. Also 34 persons of the control group with normative values. The study of the immune system was carried out at the admission of patients to the hospital before the immunotherapy course and immediately a few days before discharge from the hospital. All patients with cervical cancer received standard polychemotherapy according to the protocol of the department, a complex treatment including a two-stage combined radiation therapy. Immunological studies included the study of cellular and humoral parameters of the immune system of patients with cervical cancer. The EIPHT method was designed primarily to reduce toxic effects after chemotherapy and radiotherapy, as well as improve the overall condition after chemotherapy and radiation therapy.Results and discussionsThe analysis showed that patients with cervical cancer was found a T-cell immunodeficiency, which was associated with CD4+ - deficiency against the background of an increase in CD8 +and increased activation of lymphocytes with the predominance of apoptosis of immunocompetent cells. After carrying out EIPHT with thymalin, activation of the T-cell link of immunity is observed. The revealed imbalance of the humoral link of immunity before and after polychemotherapy and radiotherapy was associated with an imbalance of the main serum immunoglobulins and an elevated CIC level of small and large values. Against the background of the use of EIPHT with thymalin, normalisation of humoral factors of immunity and activation markers of lymphocytes is observed.ConclusionThus, the method of EIPHT in our case turned out to be promising in the treatment of cervical cancer due to the possibility of removing the effects of cancer and chemoradiation intoxication, as well as activating its own system of antitumor protection of the organism.