Abstract
IntroductionOvarian cancer (OC) is the third most common gynaecological cancer among women worldwide and it is associated with the highest mortality rate among gynaecologic malignancies. There is an urgent need to refine classification of ovarian cancer and identify novel targets. The PI3K/AKT/mTOR pathway is an intracellular signalling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation and cancer. We aimed to investigate the prognostic role of AKT in ovarian cancer.Material and methodsInvestigation of the expression of AKT in ovarian epithelial cancer was carried out on tissue microarrays of 525 consecutive ovarian epithelial cancer cases treated at Nottingham University Hospitals (NUH) between 1997 and 2010 and their expression was correlated to clinicopathological outcomes as well as to recurrence free survival (RFS).Results and discussionsHigh cytoplasmic AKT expression was significantly associated with serous type of tumour (p=0.042). Furthermore, High AKT protein expression was correlated with poor outcome in terms of Recurrence Free Survival (RFS) (p=0.034). Moreover, by selecting only stage one disease positive AKT expression showed significantly higher chance of worse RFS.ConclusionAKT protein is a prospectively valuable recurrence predictive biomarker of epithelial ovarian cancer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
