PO-0734 Effect Of Volume-targeted Ventilation In Extremely Low Birthweight Infants Under High Frequency Oscillatory Ventilation

Abstract

Background and aims Volume-targeted ventilation, or volume guarantee (VG) is known to improve neonatal prognosis in preterm infants, when added to conventional ventilation. Yet, VG effect is unclear when combined with pressure-controlled high frequency oscillatory ventilation (HFOV). The aim of this study is to investigate the effect of VG mode added to HFOV on respiratory parameters. Methods We conducted a prospective study in extremely low birthweight infants who were ventilated after 28 days of age with HFOV (Babylog VN500). VG was applied for 8 h and VG was removed for the following 8 h. Frequency (12 Hz) and mean airway pressure were fixed during study period in each case. Tidal volume, amplitude, minute volume (MV), heart rate (HR) and oxygen saturation (SpO2) data were analysed. Results Six neonates were included (gestational age 22 w 5 d-23 w 6 d, birthweight 424–584 g). Standard deviations of both SpO2 and MV with VG were significantly smaller than those without VG (Figure, pared t-test). HR fluctuation was not different. In total, desaturation episodes (SpO2). Conclusions This pilot study suggests VG added to HFOV would attenuate fluctuation of SpO2 and pCO2, which leads to prevent hypoxia and hypocapnia, possibly resulting in preferable neonatal prognosis.