PO-071 Risk factors associated with mortality from kidney diseases in patients diagnosed with multiple myeloma: a population-based analysis

Abstract

IntroductionMultiple myeloma (MM) is a neoplastic proliferation of bone marrow plasma cells that manufacture the monoclonal immunoglobulin. Kidney disease has been a principal cause of morbidity in patients with MM, and approximately, 40%–50% present with kidney function impairment at diagnosis. Many factors may manipulate the kidney function, for instance, cast nephropathy, hypercalcaemia, hyperuricaemia, infection, hyperviscosity and chemotherapeutic agents can precipitate renal damage. Herein, we aim to investigate and analyse the paramount risk factors associated with mortality due to renal diseases in MM.Material and methodsWe used the Surveillance, Epidemiology, and End Results (SEER) program for 1973–2010 and evaluated 55 991 patients with MM. Univariate and multivariate hazard regression model were used to identify potential risk factors for mortality from kidney diseases. In addition, survival curves were drawn out using the Kaplan–Meier method. The log–rank test was used to compare the survival distributions.Results and discussionsThe mortality due to kidney diseases was the third most common cause of death (5.47%) after thromboembolic events and multiple myeloma. However, the kidney diseases specific survival improved over time. Multiple myeloma specific survival rate was 42.7% while the overall survival rate at the study end points was 25.6%. Multivariate Cox Regression analysis demonstrated that increased risk of mortality due to renal diseases was associated with age ≥60 years, not-married, white race, and radiation therapy (all, p<0.001). No significant differences in survival between male and female.ConclusionThe mortality from renal affection in MM patients was associated with being elder, not-married, white race, and radiation therapy. Our considerations and further investigations of these risk factors is needful. It may promote our comprehension to MM and lessen the kidney deterioration with our prospects for improving in the overall survival.