PO-05-095 GENDER DIFFERENCES AND SAFETY OUTCOMES AFTER CATHETER ABLATION OF VENTRICULAR TACHYCARDIA

Abstract

Female patients are largely underrepresented in clinical studies pertaining to ventricular tachycardia (VT) ablation. Conflicting data exists on outcomes after catheter ablation of different arrhythmias however sparse data exists on the role of gender in safety and complication outcomes after catheter ablation of VT. To evaluate the role of gender differences in complication and safety outcomes after catheter ablation of ventricular tachycardia. Data used in the study was obtained from the National inpatient sample database for the years 2016-2019. We identified patient >18 years old who were diagnosed with ventricular tachycardia as a primary diagnosis and underwent catheter ablation during index hospitalization. We compared demographics and in hospital outcomes in the study population based on gender. The primary outcome was all cause mortality and secondary outcomes were transferred to rehab, hospital length of his stay and in-hospital complications. Univariate analysis was used to compare outcomes between genders. A total of 24,280 patients were included in our analysis, 19% female and 81% male. Male patients had significantly higher comorbidities including higher incidence of chronic kidney disease, chronic obstructive pulmonary disease, congestive heart failure, coronary artery bypass graft, coronary artery disease, diabetes, obstructive sleep apnea, peripheral vascular disease and smoking history. A significantly higher incidence of pericardial effusion (5.4% versus 3.0%, p-value 0.002) and tamponade (2.6% versus 1.3%, p-value 0.02) was noted in female patients. No other differences in complications noted between both groups. Discharge to rehab center was higher in male patients (8.2% versus 4.6%, P value 0.0012) and hospital length of stay was also higher in male patients at 6.83 days versus 5.59 days (p-value 0.01). No difference in mortality was noted between genders with mortality rate of 2.5% in females and 2.9% in males (p-value 0.53). Catheter ablation procedure for VT appears to be a safe procedure irrespective of gender. In this large nationwide study, females were found to have significantly higher rates of pericardial effusion and tamponade after VT ablation. However, no mortality difference between genders was observed.Tabled 1FemaleMaleP-ValueTotal number of patients465519625ComplicationsBleeding0.310.20.60Myocardial infarction3.84.40.42Pericardial effusion5.43.00.002Pericardiocentesis0.20.10.51Pericarditis0.50.330.43Respiratory failure0.90.70.55Tamponade2.61.30.02OutcomesDischarge to Rehab4.68.20.0012Hospital Length of Stay5.596.830.01Mortality2.52.90.53 Open table in a new tab