PNS253 Tunisian EQ-5D-5L Crosswalk-Based VALUE SET

Abstract

The 5-level EQ-5D version (EQ-5D-5L) was introduced by the EuroQol Group to improve the instrument’s sensitivity and to reduce ceiling effects, as compared with the EQ-5D-3L. The aim of this study was to develop an interim EQ-5D-5L value set. The crosswalk method developed by the EuroQol Group allows to estimate a utility value for each of the 3125 EQ-5D-5L health states based on a 3L value set through a transition-probability matrix. Following this methodology, we mapped an EQ-5D-5L value set using the Tunisian value set for the EQ-5D-3L. Both value sets were examined, values were compared in terms of mean and median utility values, distribution of values across each value set and proportions of health states considered worse than dead. Although both value sets share the same utility range [-0.79; 1], the distribution of the utilities was quite different. Higher values were observed in the EQ-5D-5L value set when compared with the EQ-5D-3L value set in terms of mean (0.31 vs 0.25), median (0.35 vs 0.28), lower quartile (0.13 vs -0.13) and proportion of health states considered to be worse than death (16.38% vs 25.9%). The same discrepancies between the original and the crosswalk value sets were observed in other studies in Poland and Sri-Lanka. The Tunisian crosswalk-based value set offers utility values for the 3125 health states described in the EQ-5D-5L. Currently, this is the only 5-Level value set available in the Arab speaking countries and therefore should be considered in studies using the EQ-5D-5L for health related quality of life measurement in the North African region.