Abstract
Background and Aims: The PNPLA3/Adiponutrin rs738409 C/G single nucleotide polymorphism is associated with the severity of steatosis, steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease, as well as with the severity of steatosis and fibrosis in patients with chronic hepatitis C (CHC). We tested in genotype 1 (G1) - CHC patients the putative association between the PNPLA3 variant and histological features of steatohepatitis, as well as their impact on the severity of fibrosis.
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